Spero Therapeutics Inc — AI technical analysis, September 2026
NYSE/NASDAQ · Biotechnology
AI Recommendation
SELL
Technical score 30/100
Last price: $1.15 · 52W range $1.08 – $3.08
Short answer
Should you buy SPRO right now? Stockgaide's AI rates SPRO as
SELL, with a technical score of
30/100 at a last price of $1.15.
The 50-day average is below the 200-day average, and RSI sits at 33.3.
Wall Street's consensus rating is 3.83/5.
Full AI analysis for SPRO
Strategic Conclusion
Recommendation: Sell
Why? The stock is in a clear medium-term downtrend, with SMA50 below SMA200 and the price sitting just above its 52-week low. Analyst consensus is negative — 0 buys, 3 holds, and 3 sells — and the technical score is 40/100, signaling sell. The low P/E of 8.91 looks cheap but is not enough to offset deteriorating price action and weak institutional/analyst support.
Ideal profile: Avoid for both short-term traders and long-term investors; only a speculative trader might attempt a tactical oversold bounce, but the risk/reward is poor.
Price range: Exit zone on any bounce: $1.30–$1.40 (near SMA50). Stop-loss for anyone still holding: below $1.05.
Practical action: Sell into strength toward $1.30–$1.40 rather than waiting for a recovery. Do not buy the dip while the stock remains below both moving averages and analysts are net negative.
1. Recent Price & Momentum
Current price is $1.13, only 4.6% above the 52-week low of $1.08 and 63% below the 52-week high of $3.08.
The stock is near the bottom of its range, not sideways and not near the top.
Short-term scenario: an oversold bounce is possible, but the path of least resistance is down. A break below $1.08 would likely trigger further selling; resistance sits at $1.38 (SMA50).
2. Valuation (P/E)
P/E TTM is 8.91, which appears low on the surface.
However, for a small-cap biotech with a $0.07B market cap, trailing earnings are unreliable and can reverse quickly. The low multiple does not necessarily mean the stock is undervalued; it may reflect depressed earnings that the market does not expect to persist.
The price already reflects weak expectations, but valuation alone is not a reason to buy given the negative technical and analyst backdrop.
3. Technical Analysis
SMA50 ($1.38) is below SMA200 ($2.19), confirming a medium-term downtrend.
RSI(14) is 29.6 — oversold, which could produce a short-term bounce, but oversold conditions can stay oversold in a downtrend.
MACD is slightly above its signal line (-0.0561 vs -0.0630) with a small positive histogram, indicating early momentum improvement, but the overall MACD level remains negative.
Technical score: 40/100 → SELL. The bearish moving-average structure outweighs the oversold RSI and minor MACD crossover.
4. Analyst Consensus
Mean rating is 3.83/5, with 0 buy, 3 hold, and 3 sell.
This is a clearly negative consensus — no analyst recommends buying, and half recommend selling.
The analyst view aligns with the technical sell signal. There is no meaningful divergence that would justify stepping in front of the downtrend.
Technical signal details
Rule-based read from price and momentum indicators only — the score behind the AI's recommendation above. Technical score: 30/100 (SELL).
50-day moving average is below the 200-day — medium-term downtrend pressure.
MACD is above its signal line — bullish momentum.
RSI at 33.33 — neutral momentum.
Wall Street consensus rating of 3.83 — analysts lean negative.
Stockgaide's AI currently rates SPRO as SELL, with a technical score of 30 out of 100 at a last price of $1.15. This is educational content, not investment advice.
Is SPRO in an uptrend?
SPRO's 50-day moving average (1.36) is below its 200-day moving average (2.19), which points to a medium-term downtrend.
What is SPRO's RSI today?
SPRO has a 14-day RSI of 33.3, which places it in neutral territory (above 70 is overbought, below 30 is oversold).
What do analysts say about SPRO?
Wall Street analysts covering SPRO have a consensus rating of 3.83 out of 5 (1 = Strong Buy), meaning they lean negative — 0 Buy · 3 Hold · 3 Sell.
Where is SPRO trading in its 52-week range?
SPRO last traded at $1.15, against a 52-week range of $1.08 to $3.08 — about 3% of the way up that range.
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